Friday, November 26, 2010

The Victoria-Magritek team

Today, my esteemed friends and colleagues, Andrew Coy, Robin Dykstra, Craig Eccles and Mark Hunter, joined me in Auckland to receive the Prime Minister's Science Prize. This is a huge honour, but best of all, the prize recognises the teamwork that has made our lab and created the company, Magritek.

Why this five? It could have been for a hundred of our wonderful collaborators, past and present. But, consistent with the narrative of "science to business to positive impacts for New Zealand", we five are the scientist shareholders who started the company. The guy with the green tie is Prime Minister John Key.

For more background see
http://www.pmscienceprizes.org.nz/about/winners_2010/science.html

Thursday, November 25, 2010

Pike River

The awful unfolding of this tragedy has dominated our thoughts since last Friday. The country is stunned. Today's Dominion Post cartoon by Tom Scott, captures that mood. One of our "folk poets", Gary McCormick, has written this.

SEVENTEEN (In memory of Joseph Ray Dunbar and all those who died in the Pike River Mine.)

Joseph Ray Dunbar was just seventeen.
One week ago - turned seventeen.
No doubt had a few drinks out
with his mates.

He'd been through a rough patch, someone said.
Who doesn't ??!
A boy from the Coast,even-eyed.
But he's gotten a job now.

New boots.
The making of him, someone said.
You get a lot of respect with a job.
Couldn't wait !

Probably had his lunch packed.
The unlined face, the big smile.
Probably had a way with the girls.
The local girls.

Couldn't wait !
The local girls are wearing black.
Mothers and sons and husbands too.
He probably ran the last hundred yards....

Joseph Ray Dunbar.
Climbed aboard and headed on down.
A smile and a wave and a joke amongst men.
The biggest day of Joseph's life.

You caught the train, Joseph.
You took the train too soon.
You caught the train before your time.


Gary McCormick reads his poem 'Seventeen' written for those who died in the Pike River mine.

http://www.stuff.co.nz/national/pike-river-mine-disaster/4386404/Audio-Gary-McCormick-poem-for-Pike-River-miners

Saturday, November 20, 2010

The Mountains of Moria

Today I had the first appointment with my Wellington oncologist, following the Sydney surgery. In preparation I had taken a blood test two days earlier.

Miang and I waited in the consulting room, expecting the usual greeting "you've lost more hair". Instead, my oncologist entered the room with a look of astonishment on his face and began, "your CEA is normal". "What concentration?", I asked. "3.0 ng/ml" was his reply. "Tell me about the surgery." I chatted with him for a while, recounting some of my extraordinary and somewhat bizarre experiences. "Not something I'd like to do every year", I said.

He asked me to lie on the bed so that he could examine my abdomen. Now I should say that the landscape of my scar-transected abdomen is more like the Mountains of Moria, than the Plains of Sixpack. I could sense him flinch as he glimpsed that landscape and started his examination, the gentle tapping of the finger with the two hands working together. He looked perturbed, and then after just a few taps he stopped. I read his mind at that moment. "Good grief, the contents of the abdomen were never like that in any anatomy lesson that I learned". He expressed that inferred thought as he recoiled from his brief examination with the words, "My goodness, you have had major surgery".

I tucked my shirt back , buttoned up and we both sat down again. We chatted some more about the new adjuvant chemotherapy course that I would start in a few weeks. The CEA data were compelling, and as you look at the graph Dear Reader, you may see that something remarkable has happened as a result of the peritonectomy. My oncologist was clearly struggling with the irreconcilable, the healing power of chemotherapy versus that of surgery. Of course, the cunning of the peritonectomy procedure is that it combines both.

"Might I suggest that you recommend this procedure to future patients who are suffering from peritoneal metastasis?", I asked, pushing the boundaries of the patient/physician relationship. He paused deep in thought for a moment and then said, "Not for everyone." I think he was still disoriented by the experience of feeling the strangeness of my abdominal interior.

I like this man very much. He is wise and kind and self-effacing, and I have forgiven him for telling me, so many months ago, that I was incurable. Perhaps he will be proven to have been right, but I think he and I now both believe that, rather than a few months, as earlier perceived, it may be a few years before we will know the answer. I thanked him, and Miang and I walked out the door with him, parting with best wishes for Christmas, and with that we strolled back out of the hospital smiling and laughing.

"Normal CEA!" I repeated several times, to Miang's evident amusement. "Better than a kick in the pants, I would say."

Tuesday, November 16, 2010

The missing cards

A curious unhelpfulness of St George Hospital showed up in their treatment of incoming mail. Several people who sent me cards had them returned, if they had a return address indicated, or if not, simply discarded. My sister's crime was to address the card in every way correctly, but to also include the line "Cancer Ward". It turns out that there is no Ward labeled precisely as such, so rather than checking the hospital's register of patients the mail receptionist simply did a "return to sender". Fortunately the medical and nursing staff at St George were less callous and lazy.

So, if you are one of those who sent a card, and received no thank you from me, please understand, I probably never received it!

Wednesday, November 10, 2010

Back home

Yesterday afternoon Miang and I flew into Wellington airport, to be greeted by my brother Jim, who had driven 2.5 hours from Wanganui to be there. As we walked out the exit passage we saw a huge sign saying "Welcome home Sir Paul", being waved over Jim's head. Thus the welcome was also an occasion for hilarity.

We drove to Khandallah in beautiful sunshine, in the absence of wind, indeed a perfect Wellington day. The balmy conditions continued to today, as we started with a local walk, and then attended to the last of the unpacking and the washing. I say "we". In truth, Miang has done nearly all, as I have felt pretty exhausted.

Now I look forward to a long summer of recuperation, hopefully building my energy levels day by day.

PS: The magnificent artwork of the sign is thanks to Jim's wife Sharron.

Saturday, November 6, 2010

Reflections on St George Hospital

Major surgery starts early in the morning, allowing the full day for the procedure. The night before, the patient anticipates the dawn. Remarkably, in my case, I slept well, waking just before the the alarm at 5-45 am. We reported in to the Day Surgery Unit at 6-30 am, to await the surgeon's visit, before my being taken into theatre. It was 8 am before he appeared, having just completed his morning ward rounds. With a few words of encouragement he left. It was to be several days before I saw him again. Miang, Mary and I exchanged a few words, and then I was wheeled to the anesthetic room, once again meeting the astrophysicist turned anesthetist, who had briefed me the day before. He removed my wedding ring, slipped a cannula into a vein in my hand, and I was gone.

In what seemed an instant, I was emerging into strange consciousness, though I was later to discover that over 24 hours had elapsed. Miang, Mary and Tom were standing beside my bed in the Intensive Care Unit, though I was unable to speak to them, because of a ventilator tube passing through my mouth. I needed to tell them something and moved my hands to indicate the action of writing. They passed me a pen and a notebook. The words I wrote were incoherent, but what I wanted to express was a memory of physical distress while young women had endlessly chatted in a sort of teenage patois, oblivious to my condition. This was the beginning of several days of morphine-induced impressions, vaguely connected with human activity or conversation within earshot, all vivid and mostly bizarre.

The periods of consciousness were initially short, perhaps only minutes, but of course, I was the least reliable witness. After another 24 hours, my ventilator tube removed, I was moved to the High Dependency Unit, where a male nurse seemed to wish to engage me in deep discussions about my scientific work, or New Zealand's social liberalism, none of which I particularly welcomed, but to which I offered polite and hopefully good-natured replies, in the least number of words possible. I was later rescued by an orderly who shifted me to a regular ward, where the nurse to patient ratio was sufficiently high to make such in depth interrogations unlikely.

Over the next days, my plumbing was gradually removed so that by the time a week had elapsed, I was able to eat, I had a functioning bowel, I was walking the ward corridors, and my self-controlled morphine line had ben removed. This clever device, known as a PCA (patient controlled analgesia), allows the patient to press a button to obtain a shot of morphine, the pump then being deactivated for 5 minutes, before a repeat is possible. This delay ensures that the drug has a sufficient sedative effect that any attempt to overdose will be preceded by the patient falling asleep by about the fourth or fifth dose . Prior to the PCA removal my sleep had been accompanied by vivid, and often very unwelcome, dreams. Even in my semi-conscious state my brain would interpret voices in the corridor in a dream-like slightly paranoid sense that these conversations involved me, or people who knew me, strange recollections of people from my distant past, here in ward 3E, St George Hospital.

On disconnection, a sense of normality returned, and my physical progress continued apace. In a bed across from me was a comrade who had has his operation two days before me. He could not hold down food and was in distress much of the time. My rapid progress was good fortune, but probably little comfort to him. I left the hospital on day 13, and for the next week visited this comrade each day. To my enormous relief, at the end of that period he suddenly improved, was able to eat food and to move about a bit.

My son tells me that a high pain threshold is helpful to surgical recovery, allowing the patient to more rapidly reduce the pain-killing drugs, with their unhelpful side effects, and to mobilize earlier, to be able to get up and walk about, again assisting the recovery process. I have something to add to that. For me, it is the horror of hospital meals, no matter how nourishing, no matter how well presented, the dread of the relentless delivery of that tray, at a time prescribed by the meals service, drives a determination to escape.

And so I have emerged, from yet another hospital experience, entertained by the distinct personalities of the medical staff, treated to extraordinary care and kindness, and throughout, uplifted by my family and friends. During my last two days in hospital, Miang, Catherine and I made plans for a summer holiday at a rented bach on the Kapiti Coast. It was an unfamiliar and most pleasant experience, to be planning for the future, albeit only a couple of months ahead. A year that had begun with a sense of closing, completing and coming to terms with the immediate term, was ending with a new lease of life. There would be next year, possibly another, and maybe further good years ahead.

Surgery is a remarkable profession in which procedures beyond the imaginative possibilities of most of us, bring about transformative change. My son, himself a surgeon, had advised me of this radical peritonectomy possibility back in April, a treatment of which my New Zealand oncological advisors were largely unaware. Yet I have much reason to thank my oncologists. They had treated me with a cocktail which significantly reduced my cancer burden, buying crucial time, time which had enabled me to organise the Sydney surgery.

For Professor David Morris and his team, I have nothing but admiration and respect. I would like to see other New Zealanders with peritoneal metastasis have the same opportunity that I have been given. That's one more plan for the future. I am going home with immense optimism.

Thursday, November 4, 2010

"On The Beach"

Just to show that I am no longer deserving of concern, and am fully ready to assume normal household duties, here is the picture of Miang and me on Brighton Beach, Botany Bay, taken yesterday by Eiichi. The site of the photo is close to where the "first fleet" arrived in Australia in 1788.

Later in the afternoon, we were joined by Sydney friend, Bill Price. Today we are packing up and about to leave for Curl Curl.

Tuesday, November 2, 2010

From Japan to the USA via Sydney

Today my old friend Eiichi Fukushima from Albuquerque, New Mexico, came to visit me in Sydney. He had been in Japan for 10 days visiting his son and his sister and took a deliberate diversion via Sydney in his journey home, to check up on me. You can imagine how touched I was by this.

What an extraordinary man he is. One of the first stories we recounted when he arrived was of a 2 day hike the two of us took in the Julian Alps of Slovenia, in 1993, when Eiichi discovered my manic side and me, his extraordinary alpine skills, and his great patience. Eiichi was part of the team who first climbed the highest mountain in Antarctica (Mt Vinson-Massif).

The first picture shows me and Eiichi in downtown Kogarah, while the second was taken at our Melbourne Cup party in Bezzina House. Later in the afternoon we were joined by Christoph Arns, a mutual friend from Sydney

PS: for the uninitiated, the Melbourne Cup is an annual horse race which causes all work in Australia and New Zealand to cease during its running.