Saturday, February 25, 2012
Paul is back in hospital
Sunday, February 19, 2012
Update - Slightly better news

Paul is still in hospital but may have finally turned a corner. He was able to eat some soup (Miang's famous chicken broth) for the first time on Sunday. There was no adverse reaction from the bowel and no nausea. Miang reports he is starting to get bored and wants to go home. Hopefully these are all good signs, and hopefully he will be home soon.
Friday, February 17, 2012
Paul in Hospital
Tuesday, February 14, 2012
Rising to the challenge
Last year I had committed myself to giving a public lecture on Zealandia, entitled "The Sanctuary Vision and its importance to New Zealand. I wondered as the due date of February 13 approached whether I could manage the task. My good friend, ecologist Professor Charles Daugherty, offered to act as understudy for me, if necessary taking over on the evening if I should falter. The venue was the Rutherford House lecture Theatre of the University. We were fully subscribed and ran an overflow video in an adjacent theatre. As it turned out, I was able to complete the lecture, sitting down from time to time to relieve the abdominal discomfort. I took a good dose of morphine in advance and it carried me through. The audience gave me a standing ovation, no doubt in part because of my completion of the mission!
That was last night. Today I have been utterly exhausted, sleeping most of the day. There has been some wonderful feedback. I understand that the lecture was videoed and when the link comes, I will publish on this blog.
And, while I remember, here is the audio link to my Rua Rautau lecture delivered at Te Herenga Waka Marae on January 29 and broadcast on national radio on Waitangi Day, February 6.
http://podcast.radionz.co.nz/wrr/wrr-20120206-2106-2012_-_sir_paul_callaghan_and_hon_luamanuvao_winnie_laban-048.mp3
Part 4 and final: Wellington
I moved my group to Victoria University of Wellington in 2001. I was ready for a change, but I had no idea just how big a change it would be. First, I ended up establishing a new research institute, the MacDiarmid Institute for Advanced Materials and Nanotechology, named after Kiwi Nobel Laureate Alan MacDiarmid. Alan, who won his prize for co-discovering conducting polymers, was a national hero. Based at the University of Pennsylvania, Alan was a regular visitor to his homeland and a great communicator of science. Being in the capital city plunged me into the world of science communication as well. Motivated by Alan’s example, I followed my route in trying to bring science to the general public, with a radio show, television documentaries, and popular science books.
Then something quite surprising happened. While at Massey University, I had started collaborating with a brilliant electronics engineer named Robin Dykstra. Robin had been with Craig and me on some of our Antarctic visits. In 2004, Robin, Craig, and I, along with my PhD student Mark Hunter, discussed the possibility of starting a company to commercialize the rheo-NMR attachments, a one-sided access NMR system that Mark had designed, and the Earth field spectrometer that Robin had improved so much, by comparison with its 1980s genesis. The company was formed in late 2004, headed by a CEO of great talent, the same ex-PhD student of mine, Andrew C
oy, who was already well known in NMR circles for his work with me on q-space diffraction. Andrew had been in the business side of IT in Sydney and London for nearly a decade. He turned up in Wellington, heard we were starting the company, and expressed his interest in running it. Magritek has never looked back, in its 6th year now, with 21 staff and with export sales of NMR systems around the world. Suddenly I had entered the world of science commercialization, and my university research group was expanded to include NMR technology, along with our continuing work in soft matter and porous media. I have had a wonderful life in magnetic resonance, learning so much from my students and collaborators. Much of what I have done, as well as the work of international colleagues, is summarized in my recent book published by OUP. I have always enjoyed dreaming up new ways of extracting information about molecules by manipulation of nuclear spins. And my particular interest in doing this is to gain insight regarding how molecules organize, align, and move about. Such insight is of some importance in helping physicists understand soft materials, self-assembly pathways to nanotechnologies, and the behavior of complex fluids and porous media. Of course, such understandings can assist a whole array of applications, from food science, to biotechnology, to biomedicine. That’s a motivational factor, but for me, it’s not the main one. It’s the beauty of magnetic resonance that holds my interest, as well as its essential veracity.
Photos: The Zealandia lecture, The Magritek founders and the PM
Sunday, February 12, 2012
A weekend of downs and ups

On Friday I awoke to the sad news that my friend Lloyd Morrison had died. Lloyd was a legendary Wellington businessman and philanthropist whom I had got to know through our shared struggle. He had acute myeloid leukemia. Lloyd had founded infrastructure investment firm, Infratil, was a prime mover behind a campaign to change the New Zealand flag, and a generous patron of the arts and the local soccer franchise, the Phoenix. He was a far-sighted visionary, unconventional, extraordinarily intelligent, and passionate about Wellington and New Zealand.
Later on Saturday my spirits were lifted by a visit from Miang's cousin Lily and her husband Anthony, who had flown over from Sydney for the weekend. Saturday was the 6th anniversay of my marriage to Miang. I joined them all later in the afternoon for a drive around the Miramar Peninsula and the South Coast, including a climb up to the Ataturk Memorial. The latter exhausted me. Walking is now quite painful for me, but I try to force myself to exercise for 30 minutes each day.
On Sunday morning Catherine texted me to say that her friend Kent Gardner had been made UK New Zealander of the year at an awards ceremony in London. Kent was behind the "Step Up for Christchurch ca
mpaign", a fundraiser involving climbing the Gherkin tower owned by his company.And this afternoon, Sunday, the weather was so beautiful that Miang and I decided to go to Pukerua Bay, the place where we had celebrated our first anniversary in 2007. She swam in the sea while I watched happily from a seat on a bank above the shore.
Part 3: Antarctica, Porous media and soft matter
Another odd area of interest for me in the 1980s was Earth field NMR. We did the first spin echo experiments using 180° audiofrequency pulses. Later, in 1994, Craig and I were to take this apparatus to Antarctica to measure brine content in sea ice. We were joined in 1996 by an American postdoctoral fellow, Joe Seymour. Joe not only contributed to our Antarctic program, measuring brine diffusion in sea ice, but also introduced me to chemical engineering, his own undergraduate specialty. Joe and I set out to see what we could do with pulsed-gradient spin echo (PGSE) NMR to measure dispersion, the process whereby molecules starting together are separated by flow. This collaboration was very fruitful, and porous media dispersion and diffusion studies became a major part of our research interests.
My Slovenian link was also revived in a wonderfully productive sabbatical visit by Janez Stepisnik. We were able to demonstrate experimentally the validity of his idea that the spectrum of molecular velocity autocorrelation functions could be measured using modulated gradient spin echo NMR. By the 1990s we had been exploring the use of NMR microscopy to study heterogeneous flow in shear cells, combining rheology with NMR, inspired by Ed Samulski, a U.S. sabbatical visitor to my lab. Our work in rheo-NMR led to another serendipitous collaboration that in tur
n generated a major field of research in my laboratory. In 1996 we were introduced to worm-like micelles (WLMs) by visiting Dutch physicist Bas Smeulders. Later, we used NMR microscopy to measure shear banding effects in WLMs, and we have been pursuing the complex rheodynamics of these systems ever since.Of all the work we have done, the most cited has been the “q-space diffraction” and “q-space imaging” research. The history of this is interesting. In a review paper on PGSE NMR, published in the Australian Journal of Physics, I pointed out the formal analogy between PGSE NMR and the incoherent fraction of inelastic neutron scattering. In neutron inelastic scattering, the symbol q is used as the reciprocal space dimension conjugate to dynamic displacement. The term “q-space” first appeared, in the NMR context, in the title of a paper on NMR velocimetry that I published with Craig Eccles and Yang Xia in Journal of Physics E, in 1988. But the impetus to see the potential of diffraction effects in diffusion studies came about as a result of a visit made in 1989 to Ken Packer’s group at BP research in the UK. Ken, of course, had been the first to see non-Gaussian echo attenuation when he carried out a PGSE NMR experiment on pipe flow. Those 1989 discussions with Ken centered on the idea that the Fourier transform of the “q-encoded” echo was the propagator for displacements, and this led to speculation as to whether diffraction effects might be seen for small-molecule diffusion in porous media. I worked though the theory of this. A simple limiting case was that of the isolated pore, where it turned out that in the long diffusion time limit, the propagator reduces to the autocorrelation function of the pore structure.
We dashed off a short paper on q-space diffraction and oscillatory echo attenuation effects to the Journal of Magnetic Resonance. Concurrently (and submitted before us to Magnetic Resonance in Medicine), Al Garroway and David Cory had come up with a similar idea, namely that the Fourier transform of the echo decay for an isolated pore was the pore autocorrelation function. Of course, the key step was to do the experiment. Working on an isolated pore was difficult (that experiment came later). It was much easier to work on an interconnected porous medium imbibed with water. The interesting theory extension to interconnected porous media was based on the idea that, in effect, the pore structure factor is convolved with the pore lattice structure and modulated by a diffusive envelope. With a reasonably ordered system, diffraction effects might be seen there. On return to New Zealand, I suggested to my PhD student Andrew Coy that he try the diffraction experiment on a close-packed monodisperse latex sphere system. The oscillatory features of diffraction were immediately evident on the echo attenuation function, and a paper in Nature, jointly with the Packer group, resulted. In a later, more detailed paper on this in the Journal of Chemical Physics, we were greatly assisted by some subtle theory insights provided by BP theorist, Dave MacGowan.
Later, Andrew and I verified the isolated pore predictions by using an array of rectangular glass microcapillaries, and this work subsequently led to a number of papers on the subject from our group. The advantage of q-space imaging is that one is not constrained by voxel signal-to-noise limitation. These days, the method is used as a contrast in medical imaging, where the distributions of displacements so obtained tell something about compartmentation of tissue, along with compartment size.
The photos are respectively of Lloyd, Miang at Pukerua Bay, and Ed and me two years ago.
Thursday, February 9, 2012
Nicholas Kurti and Erwin Hahn
In continuing these installments of my scientific reflections, I should say a little more about Nicholas Kurti and Erwin Hahn. Kurti was my scientific "grandfather", one of the brilliant Jewish refugees acquired by the Clarendon Laboratory in the 1930s. He held the record for achieving the lowest laboratory temperature of 1 millionth Kelvin when I first knew him. Nicholas was immensely kind and he and his English wife Gianna regularly hosted graduate students in their home.I first met Erwin Hahn in 1971 on one of his visits to Nicholas and Gianna Kurti in Oxford. I had the pleasure of meeting him again in Krakow in 1974. I had no idea how great was his
science. If any work ever deserved a Nobel Prize, Hahn's discovery of the spin echo certainly did. This is what I wrote of him in my 2011 book, "Translational Dynamics and Magnetic Resonance". "Of all the developments that have assisted NMR measurements of translational dynamics, none is as important as the discovery of the spin echo by Erwin Hahn in 1950. Indeed, it can be argued that the power of
the spin echo underpins all of modern NMR. The formation of the echo, with its inherent time-reversal properties, not only causes lost signals to re-appear, it also has the effect of removing some nuclear spin interactions while retaining others. Hahn pointed out that in the case where the magnetic field was inhomogeneous, the signal obtained by method was sensitive to translations of spin-bearing molecules, providing, for example, a means of measuring random Brownian motion."Erwin was to become a friend, mostly through my association with Alex Pines in Berkeley. He describes his current position as being emeritus "postdoctoral fellow" in Alex's lab!
Part 2: Pamerston North
I stayed in Oxford for another year as a postdoctoral fellow, but I was determined to go back to New Zealand to attempt the task of doing international science from my home base. My forebears, Rutherford included, just had to make the shift to expatriate status in order to do any serious science. But things were changing at home, not the least of which was the advent of cheap long-haul air travel. Suddenly NZ was connected to the world in a different way. And there were some brave pioneers from whom to take inspiration. Kiwi theoretical physicist Dan Walls had, in 1972, returned from Roy Glauber’s group at Harvard to start a school of quantum optics in NZ. Dan later became a Fellow of the Royal Society and winner of the Dirac medal and prize. Cancer claimed him too, in 1999. I returned home in late 1974 to a lectureship in Physics at Massey University, an upstart institution with an agricultural college background, and a small but feisty science faculty led by a larger-than-life biochemist, Dick Batt. Dick came from my hometown of Wanganui. Maybe that’s how I got the job. But I was grateful for the employment, and joined a small group of physics colleagues inside a larger Chemistry Department. There was no physics research equipment at all, but the chemists had just acquired a JEOL FX60 NMR spectrometer. It was just a remarkable machine, with a lovely light pen interface, the first for JEOL of the new generation of pulsed Fourier transform instruments.
The physical chemist in charge of the FX60 was a Lancastrian immigrant, Ken Jolley. I couldn’t have had a better teacher or more generous colleague. He allowed me to share in this wonder and to start a research program using the spectrometer. And being in that chemistry environment could not have been better for me as I made my transition from a rather narrow-
focused physicist to one who saw the wonders of chemistry, of the world of molecules, with all the opportunities for physics that this field of research presented. With Metka Luzar’s talk in my mind, I set about building a pulsed field gradient system that we could attach to the FX60. In that I was assisted by an able graduate student named Craig Trotter. We built the electronics and gradient coil and quickly discovered that there were some technical problems plaguing this method that were ripe for tackling. These included gradient pulse area mismatch, sample vibration, and eddy current effects. By good luck we made some progress, and that led to a fruitful period in which my collaborators and I measured polymer diffusion, as well as small molecule diffusion in anisotropic and heterogeneous environments. It wasn’t long before NMR micro imaging became a focus of our work. The apparatus building was result of a most remarkable graduate student named Craig Eccles. Craig was not only a fine physicist but also an electronics and software genius. In the mid-1980s, with Craig, and new Chinese student Yang Xia, we were using our NMR microscope to image flow in wheat grains in vivo, impossibly difficult but very effective. This work helped start a new field of research in which sub-100 micron structure was revealed in soft materials and biological tissue from the perspective of the interpenetrating liquid molecules. NMR Microscopy was the subject of my first book, published by OUP in 1991.
Photos in order: Nicholas Kurti, Alex and Erwin, Erwin and me, Ken Jolley and me.
Wednesday, February 8, 2012
What to write?
One dear friend of 40 years, Maurice Ormsby, proposed a solution to my philosophical problem in a wonderful long letter, finishing with the suggestion that I write to my grandchildren. My son suggested I write more, a sort of synopsis of my life with stories from the family. That also, I am now doing. And in starting this writing, I remembered that I had penned a brief account of my scientific life, published last year by OUP in a multi-author volume, improbably entitled "Diffusion MRI: Theory, Methods and Applications" and edited by Derek Jones. It was reprinted late last year, with permission from OUP, in Chemistry in New Zealand. I think it would be of interest to readers of my blog, and so, with indulgence from OUP, I will present it here in installments.
Part 1: Wanganui, Wellington and Oxford
I was born, and grew up in Wanganui, where physics seemed to surround me. I built my first crystal set radio while at primary school and was delighted to be able to pick up two radio stations. When I was 10 years old, Sputnik was launched, with many more satellites following, some of which could be seen at night with the naked eye, repeating their orbit after 90 minutes. In my early teens I was a boy chemist, with a backyard laboratory and pursuing adventures that would today be considered foolhardy at best, and criminal at worst. There was a 200-meter-long tunnel in a local hill that led to an elevator that allowed hilltop residents to avoid the 70-meter climb. It made wonderful echoes, over a second apart.
Among that mix of radio waves, molecules, echoes, and the evident triumph of the laws of physics may have been sown the seeds of a life in magnetic resonance (MR). Certainly I had never heard of it. I first came across MR as a final-year physics student at Victoria University of Wellington. But my interests then were in nuclear physics and solid-state physics. I discovered a field of research that combined them, the use of hyperfine interactions to orient radioactive nuclei. And so my doctoral ambitions took me, courtesy of a UK Commonwealth Scholarship, to the Clarendon Laboratory at Oxford University, where I joined the team of Nick Stone and grandfatherly mentor, Nicholas Kurti. There we used adiabatic demagnetization of paramagnetic salts to get down to 10 milliKelvin, at which temperature the hyperfine interaction would overwhelm the Boltzmann energy to cause radioactive nuclei in a ferromagnetic host metal, attached to the cold finger of the apparatus, to align, so directing their gamma rays preferentially along the quantization axis. The degree of orientation could be used as a measure of the interaction strength, so that nuclear magnetic moments or local fields could be measured. But by far the best way of precisely measuring that interaction was by sweeping an RF field in the vicinity of the Larmor frequency. At resonance, the gamma rays would suddenly change their angular distributio
n and the axial count rate would change dramatically.
So that was my introduction to magnetic resonance, a phenomenon detected through gamma emissions! It wasn’t until the last year of my DPhil that I came across Faraday detection and the mainstream. In 1973 I had the chance to go to a conference in Krakow, Poland, the 1st Specialized Colloque Ampere. It was a most remarkable meeting and one that completely changed my professional life. I knew only one person there, Erwin Hahn, a regular Oxford visitor of Nicholas Kurti. Alex Pines presented his work, Proton Enhanced Nuclear Induction Spectroscopy. Peter Mansfield spoke about nuclear magnetic resonance (NMR) diffraction in solids. Someone asked if he had seen the paper by Lauterbur, Fourier Zeugmatography, which had just come out in Nature. And a young graduate student from the Ljubliana group, Metka Luzar spoke about using pulsed magnetic field gradients to measure diffusion in liquid crystals. I was fascinated. Many years later, in the early 1990s, I met up with Metka at an NMR meeting in Portoroz, on the tiny coastline of her Slovenian homeland. I sat down next to her and said: Metka Luzar, you changed my life. I am sure she thought me quite mad. Sadly, she died of cancer less than a decade later.
Thursday, February 2, 2012
Chris
For six days Miang and I have had Chris with us. He flew back to the UK yesterday, and I have to admit, it was hard to say goodbye. He is a most extraordinary man, an accomplished surgeon, about to take up a consultant's post at Guy's Hospital in London, and an all-round wonderful person. Chris has a very kind bedside manner and he has been particularly kind to his old dad.Keeping him company in cheering me up from afar is his sister Catherine. "My daughter the lawyer, my son the doctor", I tell my Jewish friends, surely qualifies me as well.

I'm proud of them both, I have to say.
